As severity of accidents increases in beyond-design basis events (B-DBEs) conditions, ambiguity of situations increases among operators and interactions between plant systems/components and operators become more complicated. Three issues were recognized and a framework composed of three corresponding methods was introduced to address the issues on applying Human Factors Engineering (HFE) review for B-DBE conditions. The enhancing framework was applied to a scenario, Total loss of Feed Water with Misleading Indicator, as a trial. The result of the trial showed that the enhancing framework could be applied as far as task analysis was feasible for B-DBE conditions with relevant human reliability analysis method.