A point of study in the characterization of additive manufactured (AM) alloys is whether or not AM microstructure responds to external stimuli differently from conventionally manufactured alloys. Samples of Alloy 625, a nickel-based superalloy of interest, were produced by both additive manufacturing and conventional wrought methods. Samples of differing sizes were subjected to one of two different types of neutron fields during irradiation: fast neutron or reactor-spectrum neutron. Vickers microhardness measurements and transmission electron microscope images were used to analyze the differences between samples before and after they were subjected to the neutron fields. Results showed differing responses between the two fabrication methods.