A Nuclear-powered ship Engineering Simulation SYstem (NESSY) has been developed by the Japan A tomic Energy Research Institute as an advanced design tool for research and development of future marine reactors. A marine reactor must respond to changing loads and to the ship’s motions because of the ship’s maneuvering and its presence in a marine environment. The NESSY has combined programs for the reactor plant behavior calculations and the ship’s motion calculations. Thus, it can simulate reactor power fluctuations caused by changing loads and the ship’s motions. It can also simulate the behavior of water in the pressurizer and steam generators. This water sloshes in response to the ship’s motions. The performance of NESSY has been verified by comparing the simulation calculations with the measured data obtained by experiments performed using the nuclear ship Mutsu. The effects of changing loads and the ship’s motions on the reactor behavior can be accurately simulated by NESSY.