A real-time expert system (DIAREX) has been developed to diagnose plant failure and to offer a corrective operational guide for boiling water reactor (BWR) power plants. The failure diagnosis model used in DIAREX was systematically developed, based mainly on deep knowledge, to cover heuristics. Complex paradigms for knowledge representation were adopted, i.e., the process representation language and the failure propagation tree. The system is composed of a knowledge base, knowledge base editor, preprocessor, diagnosis processor, and display processor. The DIAREX simulation test has been carried out for many transient scenarios, including multiple failures, using a real-time full-scope simulator modeled after the 1100-MW(electric) BWR power plant. Test results showed that DIAREX was capable of diagnosing a plant failure quickly and of providing a corrective operational guide with a response time fast enough to offer valuable information to plant operators.