The design of a Zircaloy-2-clad uranium alloy (450 ppm carbon, 250 ppm iron, 350 ppm silicon) target that can function as a pulsed spallation neutron source on interaction of a pulsed 500-MeV proton beam with the uranium nuclei is determined by consideration of irradiation damage, energy deposition, and thermal cycling effects in the target. The designed target is comprised of eight watercooled Zircaloy-2-clad uranium alloy disks, 10 cm in diameter and 2. 7 cm thick operating at a maximum uranium alloy centerline temperature of 330°C. The production of the Zircaloy-2-clad uranium alloy disks involves remelting of the cast uranium alloy by the consumable electrode technique and bonding of the Zircaloy-2 to the uranium alloy by subjecting the composite to an isostatic-helium pressure at 840°C. The lifetime of the disks in the target before cracking of the Zircaloy-2 cladding owing to lowfrequency thermal cycling fatigue is estimated from stress calculations to be ∼500 days. The results of thermal cycling tests on a disk tend to confirm the results of the stress calculations.