The effect of target temperature on blister formation and the erosion rates associated with helium blistering has been investigated for vanadium and Type 304 stainless steel. The irradiation temperature was varied from room temperature to 900°C for vanadium targets and was varied from room temperature to 550°C for stainless-steel targets. The vanadium and stainless-steel targets were bombarded with helium ions of 0.5 MeV and of 0.1 and 0.5 MeV, respectively. The total dose was varied from 0.1 C/cm2 to 1.0 C/cm2 (6.24 × 101 ions/cm2). The results show that the degree of blistering and the erosion rates associated with blister rupture and exfoliation are strongly temperature dependent. For example, for stainless-steel samples the maximum erosion rates were observed at an irradiation temperature of ∼450°C, and the erosion rate was found to be smaller at the higher temperature of ∼550°C. For vanadium samples, the maximum erosion was observed to occur at higher temperatures than for the stainless-steel cases.