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First astatine-labeled compound shipped in the U.S.
The Department of Energy’s National Isotope Development Center (NIDC) on March 31 announced the successful long-distance shipment in the United States of a biologically active compound labeled with the medical radioisotope astatine-211 (At-211). Because previous shipments have included only the “bare” isotope, the NIDC has described the development as “unleashing medical innovation.”
Imre Pázsit, Victor Dykin
Nuclear Science and Engineering | Volume 196 | Number 3 | March 2022 | Pages 235-249
Technical Paper | doi.org/10.1080/00295639.2021.1973178
Articles are hosted by Taylor and Francis Online.
In a previous paper by Pázsit and Pál [“Multiplicity Theory Beyond the Point Model,” Ann. Nucl. Energy, Vol. 154 (2021)], a general transport theory calculation of the factorial moments of the number of neutrons emitted spontaneously from a sample was elaborated. In contrast to the original derivations by Hage and Cifarelli [“On the Factorial Moments of the Neutron Multiplicity Distribution of Fission Cascades,” Nucl. Instrum. Meth. Phys. Res. A, Vol. 236 (1985)] and Böhnel [“The Effect of Multiplication on the Quantitative Determination of Spontaneously Fissioning Isotopes by Neutron Correlation Analysis,” Nucl. Sci. Eng., Vol. 90 (1985)], also referred to as the point model, in the transport model the spatial and angular dependence of the internal fission chain is taken into account with a one-speed transport theory treatment. Quantitative results were given for a spherical item, and the bias of the point model regarding the estimation of the fission rate as compared to the more exact space-dependent model was estimated as a function of the size of the sphere and the factor.
In the present paper the formalism and the quantitative work are extended to the treatment of items with cylindrical shapes, which are more relevant in many practical applications. Results are presented for both square cylinders () and for tall () and flat () cylinders. This way the differences between the cylinder and the sphere on one hand and those between the various cylinder shapes on the other hand can be estimated. The results show that the bias depends on the geometry of the cylinder quite moderately, but similarly to the case of the sphere, the bias of the point model is quite significant for larger item sizes and values, and it is nonconservative (underestimates the fissile mass) as well.