The isomer 242mAm with a half-life of 141 yr is obtained from an (n, γ) capture reaction with 241 Am. The latter is a decay product of 241Pu. The isomer 242mAm has the highest known thermal fission cross section. The cross sections of this isomer are evaluated. Unit cell calculations show that nuclear systems with 242mAm require less fuel by a factor of 2 to 100 compared to conventional fuels. These results indicate that potential applications of americium fuel exist, particularly for space reactors.