The effects of structural vibration on the pressure and velocity fields of a two-dimensional channel flow are examined in terms of three dimensionless parameters related to the amplitude and frequency of vibration and the frictional pressure losses in the channel. Pressure-flow characteristics for the pumping system supplying fluid to the channel are varied between the extremes of the constant flow rate and constant pressure-drop modes of operation. The constant flow rate mode exhibits a larger response to the vibrating wall motion than the constant pressure-drop mode of operation. Structural motion is shown to alter both the time-averaged and dynamic pressure and velocity fields in the channel compared to the steady flow values. Pressure eddies that scale on the order of the structural dimensions arise due to the interaction of the vibrating channel wall with the mean flow field. These eddies have dimensions in between the scales of boundary layer eddies and acoustic eddies and therefore can be significant in exciting large structural vibrations in the fundamental mode through a feedback effect. The hydrodynamic mass associated with the structural vibration will be reduced due to the leakage of fluid out the ends of the channel. The effects of the wall vibration on the mean flow field should be considered for flows in narrow passages when estimating the fluid-structure inter-action forces due to the flow of a high-density fluid past a surface.