Activation techniques were employed in measurement of cross sections for the 59Co(n,p)59Fe reaction, relative to 238U fission, in the neutron energy range of 2.57 to 4.91 MeV. These and previously reported data were employed in calculation of average cross sections for this reaction in two reference fission neutron spectra: (a) 235U thermal fission and (b) 252Cf spontaneous fission.