A model for two-phase (water-vapor) flow in two-dimensional Cartesian or cylindrical coordinates is described that is implemented in the code DRIX-2D. The model includes slip between the phases and accounts for thermodynamic nonequilibrium. The code was designed as a “best-estimate” model for simulation of loss-of-coolant accidents (LOCAs) in light water reactor safety analysis. In this paper results of DRIX-2D applications are reported that can be used to assess the validity of simplified LOCA models. The main results are that both Cartesian and axisymmetric coordinates in two dimensions show considerable disadvantages as far as the pressure history in the downcomer is concerned. Yet, both models yield acceptable results concerning the gross blowdown behavior. Due to a 90-deg change in flow direction, considerable radial profiles in mass flow rate, velocity, and void fraction establish in the blowdown pipe. Nevertheless, a minor difference in the averaged mass flow rate exists only between a one- and two-dimensionally modeled blowdown pipe. A nonequilibrium state establishes at the pipe inlet in the case of subcooled vessel conditions and is maintained up to the orifice at least for pipe lengths <5m. However, the increase in mass flow rate caused by this nonequilibrium state is generally small enough for typical reactor conditions, so that an equilibrium assumption in the blowdown pipe should be appropriate for LOCA calculations.