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This division promotes the development and timely introduction of fusion energy as a sustainable energy source with favorable economic, environmental, and safety attributes. The division cooperates with other organizations on common issues of multidisciplinary fusion science and technology, conducts professional meetings, and disseminates technical information in support of these goals. Members focus on the assessment and resolution of critical developmental issues for practical fusion energy applications.
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April 3–5, 2025
Albuquerque, NM|The University of New Mexico
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First astatine-labeled compound shipped in the U.S.
The Department of Energy’s National Isotope Development Center (NIDC) on March 31 announced the successful long-distance shipment in the United States of a biologically active compound labeled with the medical radioisotope astatine-211 (At-211). Because previous shipments have included only the “bare” isotope, the NIDC has described the development as “unleashing medical innovation.”
S. P. Pederson, R. A. Forster, T. E. Booth
Nuclear Science and Engineering | Volume 127 | Number 1 | September 1997 | Pages 54-77
Technical Paper | doi.org/10.13182/NSE97-A1921
Articles are hosted by Taylor and Francis Online.
The problem of obtaining valid confidence intervals based on estimates from sampled distributions using Monte Carlo particle transport simulation codes such as MCNP is examined. Such intervals can cover the true parameter of interest at a lower than nominal rate if the sampled distribution is extremely right-skewed by large tallies. Modifications to the standard theory of confidence intervals are discussed and compared with some existing heuristics, including batched means normality tests. Two new types of diagnostics are introduced to assess whether the conditions of central limit theorem-type results are satisfied: The relative variance of the variance determines whether the sample size is sufficiently large, and estimators of the slope of the right tail of the distribution are used to indicate the number of moments that exist. A simulation study is conducted to quantify the relationship between various diagnostics and coverage rates and to find sample-based quantities useful in indicating when intervals are expected to be valid. Simulated tally distributions are chosen to emulate behavior seen in difficult particle transport problems. Measures of variation in the sample variance s2 are found to be much more effective than existing methods in predicting when coverage will be near nominal rates. Batched means tests are found to be overly conservative in this regard. A simple but pathological MCNP problem is presented as an example of "false" convergence using existing heuristics. The new methods readily detect the false convergence and show that the results of the problem, which are a factor of 4 too small, should not be used. Recommendations are made for applying these techniques in practice, using the statistical output currently produced by MCNP.