A perturbation method is described for the calculation of the heterogeneity effects on the multiplication factor and on the flux in fast reactors. It differs from the conventional perturbation method in that it uses an adjoint flux that is different from, but simply related to, the conventional adjoint. This new adjoint flux follows from the use of the collision-probability concept in the integral transport equation. The first-order changes in both the multiplication factor and the flux are simply expressed in terms of the conventional flux and adjoint flux obtained from homogeneous calculations. A procedure is described for the computation of higher-order changes. Qualitative results, as well as numerical results, are given. The application of the method to Doppler calculations in heterogeneous reactors is outlined.