Natural dysprosium was irradiated by 3 × 1021 n/cm2, more than twice that previously reported. The cross section relative to the initial value dropped to 35% for 1 × 1021 n/cm2, then varied more slowly to about 25% at the maximum exposure. Good agreement was obtained between theoretical calculations and experimental results, including the isotopic distribution in the irradiated samples. Thermal cross sections and infinitely dilute resonance-absorption integrals of five major isotopes and the natural element were measured and used in the above calculations. These values are tabulated below; Of note is significant resonance integral for 160Dy for which no parameters have been reported.