This work presents a numerical study of blast venting through various blanket configurations in the HYLIFE ICF reactor design. The study uses TSUNAMI — a multi-dimensional, high-resolution, shock tracking code — to predict the momentum exchange and gas dynamics for blast venting in complex geometries. In addition, the study presents conservative predictions of wall loading by gas shock and impulse delivered to the protective liquid blanket. Configurations used in the study include both 2700 MJ and 350 MI fusion yields per pulse for 5 meter and 3 meter radius reactor chambers. For the former, an annular jet array is used for the blanket geometry, while in the latter, both annular jet array as well as slab geometries are used. Results of the study indicate that blast venting and wall loading will be strongly affected by the choice of blanket configuration.