High resolution tritium NMR spectroscopy is a neglected technique. Although it may be performed on almost any modern NMR spectrometer, there are only a handful of sites actively using this method for analysis of their tritiated materials. The utility of the technique has been demonstrated in many applications, including:

  • catalysis and hydrogen isotope exchange
  • elucidation of biosynthetic pathways
  • studies of metabolism
  • measurement of the optical and radiochemical purity of radiopharmaceuticals.
Several of these applications are illustrated here, along with some advantages of modern NMR techniques.