Activation analysis has been conducted for several primary fusion blanket materials based on a model of a commercial tokamak fusion reactor design, STARFIRE. The blanket materials studied include two solid tritium breeders, viz., Li20 and α-LiAl02, and four candidate structural materials, viz., PCA stainless steel, V15Cr5Ti, Ti6Al4V, and Al-6063 alloys. The importance of breeder material activation is identified in terms of its impurity contents such as potassium, iron, nickel, molybdenum, and zirconium trace elements. The breeder activation is also discussed with regard to its potential for recycling and its impact on the lithium resource requirements. The structural material activation is analyzed based on two measures, volumetric radioactivity concentration and contact biological dose due to decay gamma emission. Using the radioactivity concentration measure, it is revealed that a substantial advantage exists from a viewpoint of radwaste management, which is inherent in fusion reactor designs based on potential low-activation alloys such as V15Cr5Ti, Ti6Al4V, and Al-6063. On the other hand, from the dose standpoint, the V15Cr5Ti alloy is found to be the only alloy for which one could realize a significant dose reduction (below 2.5 mrem/h) within ∼100 yr after shutdown, possibly by some extrapolation on alloy purification techniques.