The performances of three different types of innovative transmutation systems have been investigated in order to assess in a comparative way their potential to manage nuclear waste arising in a geographical region, where different countries have different policies with respect to nuclear energy development, but share the objective of a common optimized waste management strategy in order to minimize the waste masses sent to a geological repository. The three systems are 1) a critical low conversion ratio fast reactor (LCFR); 2) an accelerator driven system (ADS) and 3) a hybrid fission-fusion system (FFH). In order to simplify the comparison, the three systems have been loaded with comparable fuels, in particular with the same Pu to Minor Actinides (MA) ratio. A waste management scenario study has been performed: the results show that, apart from the technological readiness of each single option, the performances, in terms e.g. of time needed to eliminate specific spent fuel inventories or in terms of reduction of decay heat and radiotoxicity in a deep geological repository, are rather comparable.