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Isotopes & Radiation
Members are devoted to applying nuclear science and engineering technologies involving isotopes, radiation applications, and associated equipment in scientific research, development, and industrial processes. Their interests lie primarily in education, industrial uses, biology, medicine, and health physics. Division committees include Analytical Applications of Isotopes and Radiation, Biology and Medicine, Radiation Applications, Radiation Sources and Detection, and Thermal Power Sources.
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Utility Working Conference and Vendor Technology Expo (UWC 2024)
August 4–7, 2024
Marco Island, FL|JW Marriott Marco Island
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The Standards Committee is responsible for the development and maintenance of voluntary consensus standards that address the design, analysis, and operation of components, systems, and facilities related to the application of nuclear science and technology. Find out What’s New, check out the Standards Store, or Get Involved today!
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Fusion Science and Technology
Latest News
Vogtle-3 shuts down for valve issue
One of the new Vogtle units in Georgia was shut down unexpectedly on Monday last week for a valve issue that has been investigated and repaired. According to multiple local news outlets, Georgia Power reported on July 17 that unit 3 was back in service.
Southern Company spokesperson Jacob Hawkins confirmed that Vogtle-3 went off line at 9:25 p.m. on July 8 “due to lowering water levels in the steam generators caused by a valve issue on one of the three main feedwater pumps.”
Junya Kobayashi, Michiyo Okui, Kenshi Komatsu, David J. Chen
Fusion Science and Technology | Volume 60 | Number 3 | October 2011 | Pages 1186-1189
Biology | Proceedings of the Ninth International Conference on Tritium Science and Technology | doi.org/10.13182/FST11-A12627
Articles are hosted by Taylor and Francis Online.
Werner syndrome (WS) is an autosomal recessive disorder associated with premature aging and cancer predisposition caused by mutations at the WRN gene. Several recent reports suggest that accumulation of DNA damage could lead to premature cellular aging. Therefore, WRN might function in DNA damage response, particularly DNA repair. Here, we investigated the role of WRN in DNA repair and genome integrity. WRN protein rapidly accumulated at DNA damage sites and formed discrete nuclear foci only during S phase, but not in G1 phase. WRN-defective WS cells showed the spontaneous accumulation of -H2AX (DSB marker), suggesting that WRN could function to repair the S phase-dependent DNA damage. However, WS cells showed homologous recombination (HR) at normal level, although HR repair functions preferentially during the S phase. Translesion DNA synthesis (TLS) is known as another repair pathway for S phase-dependent DNA damage. WS cells exhibit an increase in spontaneous focus formation of pol and Rad18, which are important for TLS regulation. WS cells also showed the spontaneous ubiquitination of PCNA and increased pol-related gene mutation. Taken together, WRN could work for the regulation of TLS pathway and might also be important to maintain genome integrity under a little DNA damage by tritium.